BIOMAT Database Logo BIOMAT Database Logo

Induction of specific-locus and dominant lethal mutations in male mice by trophosphamide. 1994

U H Ehling, and A Neuhäuser-Klaus
GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, Institut für Säugetiergenetik, Neuherberg, Oberschleissheim, Germany.

Trophosphamide induced dominant lethal and specific-locus mutations in spermatozoa and spermatids of mice. The induction pattern of specific-locus and dominant lethal mutations shows two maxima in the mating intervals 1-4 and 9-16 days post treatment. The nature of induced mutations is suggested to be intergenic.

UI MeSH Term Description Entries
D008297 Male Males
D008809 Mice, Inbred C3H An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research. Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D005260 Female Females
D005799 Genes, Dominant Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state. Conditions, Dominant Genetic,Dominant Genetic Conditions,Genetic Conditions, Dominant,Condition, Dominant Genetic,Dominant Gene,Dominant Genes,Dominant Genetic Condition,Gene, Dominant,Genetic Condition, Dominant
D005804 Genes, Lethal Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability. Alleles, Lethal,Allele, Lethal,Gene, Lethal,Lethal Allele,Lethal Alleles,Lethal Gene,Lethal Genes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy

Related Publications

U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations in male mice by fosfestrol.
July 1979, Archives of toxicology,
U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations by alkylating agents in male mice.
January 1968, Mutation research,
U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations in male mice by potassium dichromate.
March 1982, Mutation research,
U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations by Ascaris trypsin inhibitor in male mice.
January 2010, Reproductive toxicology (Elmsford, N.Y.),
U H Ehling, and A Neuhäuser-Klaus
Dominant lethal mutations in male mice.
September 1977, Archives of toxicology,
U H Ehling, and A Neuhäuser-Klaus
Lack of induction of dominant lethal mutations in male mice by nalidixic acid.
December 1980, Toxicology letters,
U H Ehling, and A Neuhäuser-Klaus
Dimethyl methyl phosphonate induction of dominant lethal mutations in male mice.
January 1984, Mutation research,
U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations by combined X-ray-acrylamide treatment in male mice.
October 1990, Mutation research,
U H Ehling, and A Neuhäuser-Klaus
Induction of specific-locus mutations in male mice by diethyl sulfate (DES)
October 1989, Mutation research,
U H Ehling, and A Neuhäuser-Klaus
Induction of dominant lethal mutations after exposure of male mice to cyclophosphamide.
January 1998, Roczniki Panstwowego Zakladu Higieny,
Copied contents to your clipboard!