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Suicide risk after attempted suicide, as predicted by cerebrospinal fluid (CSF) monoamine metabolite concentrations, was studied in a sample of 92 psychiatric mood disorder inpatients admitted shortly after attempting suicide. The potential of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the CSF to predict suicide risk within the first year after attempted suicide was studied by means of survival analysis after after median split subgrouping. Eleven patients (12%) committed suicide within 1 year after attempted suicide. Eight of these belonged to the below-the-median (< 87 nM) CSF 5-HIAA subgroup, that is, the suicide risk was 17% as compared with 7% among those with above-the-median CSF 5-HIAA. The cumulative number of survived patient-months during the first year after attempted suicide was significantly lower in the low CSF 5-HIAA subgroup. It was concluded that low CSF 5-HIAA predicts short-range suicide risk after attempted suicide in mood disorder psychiatric inpatients. These findings lend further support to the serotonin hypothesis of suicide risk.
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C Nordin, and
L Bertilsson
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Schizophrenia research,
P Nordström, and
M Samuelsson, and
M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
C Nordin, and
L Bertilsson
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P Nordström, and
M Samuelsson, and
M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
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L Bertilsson
September 1990,
The American journal of psychiatry,
P Nordström, and
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M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
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L Bertilsson
January 2006,
Archives of suicide research : official journal of the International Academy for Suicide Research,
P Nordström, and
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M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
C Nordin, and
L Bertilsson
March 1985,
Acta psychiatrica Scandinavica,
P Nordström, and
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L Träskman-Bendz, and
A Aberg-Wistedt, and
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L Bertilsson
October 1983,
Lancet (London, England),
P Nordström, and
M Samuelsson, and
M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
C Nordin, and
L Bertilsson
January 1997,
Indian journal of psychiatry,
P Nordström, and
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L Träskman-Bendz, and
A Aberg-Wistedt, and
C Nordin, and
L Bertilsson
October 2013,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
P Nordström, and
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L Träskman-Bendz, and
A Aberg-Wistedt, and
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L Bertilsson
November 1995,
Acta psychiatrica Scandinavica,
P Nordström, and
M Samuelsson, and
M Asberg, and
L Träskman-Bendz, and
A Aberg-Wistedt, and
C Nordin, and
L Bertilsson
April 2007,
Psychiatry research,
