BIOMAT Database Logo BIOMAT Database Logo

Hepatitis C virus (HCV) viremia in human immunodeficiency virus-seronegative and -seropositive patients with indeterminate HCV recombinant immunoblot assay. 1994

P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Service d'Hépatologie, INSERM U24, Hôpital Beaujon, Clichy, France.

Positivity of recombinant immunoblot assay (RIBA) for detection of antibodies to hepatitis C virus (anti-HCV) is usually associated with HCV viremia. The significance of an indeterminate RIBA result, defined by reactivity to only one HCV antigen, is unclear. Whether anti-human immunodeficiency virus (HIV)-negative or -positive subjects with an indeterminate RIBA have HCV viremia detectable by polymerase chain reaction was investigated. An indeterminate RIBA was found in 48 (15%) of 318 anti-HIV-negative and 38 (23%) of 167 anti-HIV-positive subjects (P < .05). Clinical stage was IV-C-1 or IV-C-2 in 82% of those anti-HIV-positive. HCV viremia was found more frequently in anti-HIV-positive (89%) than in anti-HIV-negative subjects (50%) with an indeterminate RIBA (P < .05). These results suggest an impaired anti-HCV response associated with HIV infection.

UI MeSH Term Description Entries
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006508 Hepatitis Antibodies Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis. Antibodies, Hepatitis
D006526 Hepatitis C INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown. Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted,Parenterally-Transmitted Non-A, Non-B Hepatitis,PT-NANBH,Parenterally Transmitted Non A, Non B Hepatitis
D006679 HIV Seropositivity Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV). AIDS Seroconversion,AIDS Seropositivity,Anti-HIV Positivity,HIV Antibody Positivity,HIV Seroconversion,HTLV-III Seroconversion,HTLV-III Seropositivity,AIDS Seroconversions,AIDS Seropositivities,Anti HIV Positivity,Anti-HIV Positivities,Antibody Positivities, HIV,Antibody Positivity, HIV,HIV Antibody Positivities,HIV Seroconversions,HIV Seropositivities,HTLV III Seroconversion,HTLV III Seropositivity,HTLV-III Seroconversions,HTLV-III Seropositivities,Positivities, Anti-HIV,Positivities, HIV Antibody,Positivity, Anti-HIV,Positivity, HIV Antibody,Seroconversion, AIDS,Seroconversion, HIV,Seroconversion, HTLV-III,Seroconversions, AIDS,Seroconversions, HIV,Seroconversions, HTLV-III,Seropositivities, AIDS,Seropositivities, HIV,Seropositivities, HTLV-III,Seropositivity, AIDS,Seropositivity, HIV,Seropositivity, HTLV-III
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000410 Alanine Transaminase An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2. Alanine Aminotransferase,Glutamic-Pyruvic Transaminase,SGPT,Alanine-2-Oxoglutarate Aminotransferase,Glutamic-Alanine Transaminase,Alanine 2 Oxoglutarate Aminotransferase,Aminotransferase, Alanine,Aminotransferase, Alanine-2-Oxoglutarate,Glutamic Alanine Transaminase,Glutamic Pyruvic Transaminase,Transaminase, Alanine,Transaminase, Glutamic-Alanine,Transaminase, Glutamic-Pyruvic
D000956 Antigens, Viral Substances elaborated by viruses that have antigenic activity. Viral Antigen,Viral Antigens,Antigen, Viral
D012367 RNA, Viral Ribonucleic acid that makes up the genetic material of viruses. Viral RNA
D014766 Viremia The presence of viruses in the blood. Viremias

Related Publications

P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Significance of indeterminate third-generation hepatitis C virus recombinant immunoblot assay.
January 1996, Journal of clinical microbiology,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns.
May 1995, Journal of clinical microbiology,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Third-generation recombinant immunoblot assay to confirm hepatitis C virus-indeterminate serological samples.
January 1993, Vox sanguinis,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Hepatitis C virus infection in blood donors with indeterminate results in second-generation recombinant immunoblot assay.
June 1994, Transfusion,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Hepatitis C virus (HCV)-specific T-cell responses among recombinant immunoblot assay-3-indeterminate blood donors: a confirmatory evidence of HCV exposure.
July 2009, Transfusion,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Significance of highly positive c22-3 "indeterminate" second-generation hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) and resolution by third-generation HCV RIBA.
May 1994, Journal of clinical microbiology,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Indeterminate results of the second-generation hepatitis C virus (HCV) recombinant immunoblot assay: significance of high-level c22-3 reactivity and influence of HCV genotypes.
January 1997, Journal of clinical microbiology,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Epidemiological, biological and histological characterization of patients with indeterminate third-generation recombinant immunoblot assay antibody results for hepatitis C virus.
March 2006, Journal of viral hepatitis,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Recombinant immunoblot assay for hepatitis C virus antibody in chronic hepatitis.
January 1992, Archives of virology. Supplementum,
P Marcellin, and M Martinot-Peignoux, and A Elias, and M Branger, and F Courtois, and R Level, and S Erlinger, and J P Benhamou
Vertical transmission of hepatitis C virus infection: usefulness of viremia detection in HIV-seronegative hepatitis C virus-seropositive mothers.
January 1998, The Journal of pediatrics,
Copied contents to your clipboard!