Biomaterial Database

Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. 1994

A M al-Bekairi, and A M al-Rajhi, and M Tariq

Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined. Pretreatment of rats with (+/-)-verapamil (4-16 mg kg-1 orally) significantly decreased cold-stress-induced gastric ulcers and enhanced ethanol-induced ulcers. It did not affect indomethacin- (30 mg kg-1 orally) or reserpine- (5 mg kg-1 i.p.) induced ulcers. Pretreatment of the animals with hydralazine (1-10 mg kg-1 orally) significantly enhanced ethanol-, reserpine- and cold-stress-induced ulcers. It did not affect indomethacin-induced ulcers. Pretreatment of the animals with verapamil increased gastric mucus secretion, inhibited gastric acid secretion, decreased glutathione content and enhanced gastric lipid peroxidation whereas pretreatment of the animals with hydralazine significantly decreased gastric mucus secretion. Hydralazine did not affect gastric acid secretion, glutathione or gastric lipid peroxidation. The results of this study suggest that verapamil-induced protection against stress-induced ulcer may be due to its ability to suppress gastric acid secretion and to increase gastric mucus secretion. Its enhancement of ethanol-induced ulcers may be due to its ability to increase lipid peroxidation. The hydralazine-induced enhancement of the experimentally-induced ulcers may be due to its ability to suppress gastric mucus secretion.

UI	MeSH Term	Description	Entries
D007213	Indomethacin	A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.	Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D008297	Male		Males
D012110	Reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.	Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005744	Gastric Acid	Hydrochloric acid present in GASTRIC JUICE.	Hydrochloric Acid, Gastric,Acids, Gastric,Acids, Gastric Hydrochloric,Gastric Acids,Gastric Hydrochloric Acid,Gastric Hydrochloric Acids,Hydrochloric Acids, Gastric
D005752	Gastric Mucins	Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.	Gastric Mucin,Mucin, Gastric,Mucins, Gastric
D006830	Hydralazine	A direct-acting vasodilator that is used as an antihypertensive agent.	Hydrallazin,Apresoline,Apressin,Apressoline,Hydralazine Hydrochloride,Hydralazine mono-Hydrochloride,Hydrazinophthalazine,Nepresol,Hydralazine mono Hydrochloride,Hydrochloride, Hydralazine,mono-Hydrochloride, Hydralazine
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013276	Stomach Ulcer	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	Gastric Ulcer,Gastric Ulcers,Stomach Ulcers,Ulcer, Gastric,Ulcer, Stomach,Ulcers, Gastric,Ulcers, Stomach