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The thermal damage threshold of normal brain tissue was evaluated from immediate and delayed histological changes caused by hyperthermia treatment of normal monkey (Macaca fuscata) brains. A 2450 MHz microwave antenna and an antenna cooling system devised by our group were used for interstitial hyperthermia treatment. The antenna within the cooling system was inserted through a small craniectomy under general anesthesia. The temperature at a reference point, 4 mm radially away from the surface of the cooling system, was maintained at 42, 43, 44, 45, or 46 degrees C for 60 minutes. Eighteen animals were treated and sacrificed immediately after the treatment, while nine animals were treated and sacrificed 7 days after the treatment. The histological changes were studied microscopically on sections stained with HE or Kluver-Barrera's method. The non-survival experiment demonstrated that areas heated at 44 degrees C or below showed no obvious irreversible changes. The survival experiment showed areas heated at 44 degrees C or above developed coagulative necrosis. These histological findings indicate that thermal damage occurs in normal brain tissue after heating at 44 degrees C or above for 60 minutes, suggesting that the safety limit for brain hyperthermia is 43 degrees C for 60 minutes.
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
January 1994,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
July 1996,
Photochemistry and photobiology,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
June 2003,
Acta medica Okayama,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
December 1977,
National Cancer Institute monograph,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
January 2014,
Brain stimulation,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
October 1971,
Journal of neuropathology and experimental neurology,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
January 1991,
Lasers in surgery and medicine,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
April 2020,
Biomedical optics express,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
May 1986,
Radiation research,
N Matsumi, and
K Matsumoto, and
N Mishima, and
E Moriyama, and
T Furuta, and
A Nishimoto, and
K Taguchi
April 2016,
Technology and health care : official journal of the European Society for Engineering and Medicine,
