-transparent.png){kind=logo}
Careful handling and preparation of freshly harvested vessels from 22 pigs and 12 rabbits revealed a two-phase vasorelaxation response to cumulative doses of substance P (SP). A rapid, transient relaxation was observed during the cumulative dose-response and a new plateau of equilibrium was seen following an increase in developed force after the last dose of SP. The phase 2 response is also produced by submaximal doses of SP and is not altered by pretreatment of the rings with Indomethacin. Acetylcholine (ACh) caused an endothelium-dependent relaxation but without evidence of a phase 2 plateau. N omega-Nitro-L-Arginine (L-NNA) and N omega-Nitro-L-Arginine Methylester (L-NAME) pretreatment resulted in a shift to the right in the phase 1 response to SP and a complete blockade of phase 2. Methylene blue caused nearly complete block of both phases. Nitroglycerin caused a dose-dependent and prolonged vasorelaxation with no phase 2.
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
June 1991,
Journal of cardiovascular pharmacology,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
July 1987,
Mayo Clinic proceedings,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
May 1994,
The American journal of physiology,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
September 1997,
Hypertension (Dallas, Tex. : 1979),
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
January 1988,
Folia haematologica (Leipzig, Germany : 1928),
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
March 1994,
The American journal of physiology,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
November 2001,
Stroke,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
April 1998,
The Journal of physiology,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
December 1984,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
D R Gross, and
R R Fiscus, and
W A Arden, and
R H Maley, and
S Lanzo, and
R K Salley
December 2008,
Life sciences,
