-transparent.png){kind=logo}
The synthesis and structure-activity relationships of a series of aza-tricyclic analogs of the quinuclidine substance P (SP) antagonist 1 are described. The SP receptor affinity of these compounds was found to vary according to the size of the new ring fused to the quinuclidine and the mode of fusion. Correlations between receptor affinity and (1) the steric bulk of the newly introduced ring fusion and (2) the dihedral angle between the benzhydryl and benzylamino substituents of these aza-tricyclic compounds were explored.
Related Publications
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
January 1982,
European journal of pharmacology,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
October 1984,
British journal of pharmacology,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
December 1986,
Journal of dental research,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
January 1993,
Agents and actions. Supplements,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
June 1984,
Biochimica et biophysica acta,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
June 1991,
Farmaco (Societa chimica italiana : 1989),
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
April 1981,
Acta physiologica Scandinavica,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
March 1984,
European journal of pharmacology,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
July 1983,
European journal of pharmacology,
J A Lowe, and
S E Drozda, and
S McLean, and
D K Bryce, and
R T Crawford, and
R M Snider, and
K P Longo, and
A Nagahisa, and
M Tsuchiya
December 1981,
Biochemical and biophysical research communications,
