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The association of occupational exposure to 1,3-butadiene and chromosomal damage in peripheral blood lymphocytes was studied in 40 workers from two production facilities. Control persons, 30 in all, were chosen from other departments of the same plants, and they were roughly matched for age and smoking habits. The exposure levels to ambient butadiene were measured both by personal sampling using diffuse monitors and by stationary sampling at production and handling sites. Chromosome aberrations (CA), micronuclei (MN) and sister-chromatid exchanges (SCE) in peripheral lymphocytes were analyzed as markers of exposure. Smoking had a slight effect on the frequency of MN, and the mean frequency of SCEs was also higher in smokers than in non-smokers. No effect of smoking, however, was seen in relation to chromosomal aberrations. No exposure related effects were seen in any of the three cytogenetic endpoints in either of the butadiene production plants, representing typical low (below 3 ppm) exposure levels of the butadiene manufacturing industry.
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
February 1987,
Lancet (London, England),
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
June 1990,
Environmental health perspectives,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
January 1993,
IARC scientific publications,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
March 1996,
Mutagenesis,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
September 2017,
Scandinavian journal of work, environment & health,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
April 2004,
Toxicology letters,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
October 1996,
Environmental health perspectives,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
August 2014,
Journal of chromatography. A,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
September 2010,
The Science of the total environment,
M Sorsa, and
K Autio, and
N A Demopoulos, and
H Järventaus, and
P Rössner, and
R J Srám, and
G Stephanou, and
D Vlachodimitropoulos
June 2001,
Chemico-biological interactions,
