BIOMAT Database Logo BIOMAT Database Logo

Expression of adhesion molecules on human hematopoietic progenitor cells at different maturational stages. 1994

M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan.

In this report we examined the expression of several adhesion molecules on human hematopoietic progenitor cells at different maturational stages. Human hematopoietic progenitor cell-enriched fractions were prepared from bone marrow cells by depleting lymphocytes and monocytes (CD2+, CD14+ and CD19+ cells). These cells were separated into adhesion molecule-positive and -negative cell populations by immunomagnetic separation methods and then assessed for their ability to form various colony forming cells (CFC). CD44 and CD49d were expressed on multipotent hematopoietic progenitor cells, or mixed colony forming units (CFU-Mix), erythroid burst forming units (BFU-E), granulocyte-macrophage CFU (CFU-GM) and erythroid CFU (CFU-E). Leu8 was expressed on CFU-Mix, BFU-E and some populations of CFU-GM, but not CFU-E. CD11a was expressed on some populations of CFU-Mix, CFU-GM and BFU-E. CD54 was expressed only on some populations of CFU-GM. These results suggest that Leu8, CD44, CD49d and CD11a appear to play important roles in the differentiation and proliferation of human hematopoietic progenitor cells at different maturational stages in the bone marrow microenvironment.

UI MeSH Term Description Entries
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D002448 Cell Adhesion Adherence of cells to surfaces or to other cells. Adhesion, Cell,Adhesions, Cell,Cell Adhesions
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003114 Colony-Forming Units Assay A cytologic technique for measuring the functional capacity of stem cells by assaying their activity. Clonogenic Cell Assay,Stem Cell Assay,Clonogenic Cell Assays,Colony Forming Units Assays,Colony-Forming Units Assays,Stem Cell Assays,Assay, Clonogenic Cell,Assay, Colony-Forming Units,Assay, Stem Cell,Assays, Clonogenic Cell,Assays, Colony-Forming Units,Assays, Stem Cell,Colony Forming Units Assay
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015703 Antigens, CD Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation. CD Antigen,Cluster of Differentiation Antigen,Cluster of Differentiation Marker,Differentiation Antigens, Leukocyte, Human,Leukocyte Differentiation Antigens, Human,Cluster of Differentiation Antigens,Cluster of Differentiation Markers,Antigen Cluster, Differentiation,Antigen, CD,CD Antigens,Differentiation Antigen Cluster,Differentiation Marker Cluster,Marker Cluster, Differentiation
D015815 Cell Adhesion Molecules Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis. Cell Adhesion Molecule,Intercellular Adhesion Molecule,Intercellular Adhesion Molecules,Leukocyte Adhesion Molecule,Leukocyte Adhesion Molecules,Saccharide-Mediated Cell Adhesion Molecules,Saccharide Mediated Cell Adhesion Molecules,Adhesion Molecule, Cell,Adhesion Molecule, Intercellular,Adhesion Molecule, Leukocyte,Adhesion Molecules, Cell,Adhesion Molecules, Intercellular,Adhesion Molecules, Leukocyte,Molecule, Cell Adhesion,Molecule, Intercellular Adhesion,Molecule, Leukocyte Adhesion,Molecules, Cell Adhesion,Molecules, Intercellular Adhesion,Molecules, Leukocyte Adhesion
D046508 Culture Techniques Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types. Culture Technique,Technique, Culture,Techniques, Culture
D019041 L-Selectin Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules. Antigens, CD62L,CD62L Antigens,LECAM-1,CD62L Antigen,L Selectin,LAM-1,Leu-8 Antigen,Leukocyte Adhesion Molecule, LAM-1,Mel-14 Antigen,TQ1 Antigen,Antigen, CD62L,Antigen, Leu-8,Antigen, Mel-14,Antigen, TQ1,Leu 8 Antigen,Leukocyte Adhesion Molecule, LAM 1,Mel 14 Antigen,Selectin, L

Related Publications

M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
[Biological characteristics of hematopoietic progenitor cells at different stages of hematopoietic development].
October 2009, Sheng li xue bao : [Acta physiologica Sinica],
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells.
January 2000, Stem cells (Dayton, Ohio),
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
CD84 expression on human hematopoietic progenitor cells.
September 2003, Experimental hematology,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages.
November 2004, Gene expression patterns : GEP,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.
April 2008, American journal of obstetrics and gynecology,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Signal transmission through MHC class II molecules in a human B lymphoid progenitor cell line: different signaling pathways depending on the maturational stages of B cells.
January 1994, Microbiology and immunology,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood.
May 1995, Stem cells (Dayton, Ohio),
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
[Fas antigen expression on human hematopoietic progenitor cells].
July 1996, Nihon rinsho. Japanese journal of clinical medicine,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Expression of Thy-1 on human hematopoietic progenitor cells.
May 1993, The Journal of experimental medicine,
M Kobayashi, and M Imamura, and T Uede, and K Sakurada, and S Maeda, and H Iwasaki, and Y Tsuda, and M Musashi, and T Miyazaki
Expression of homing-associated cell adhesion molecule (H-CAM/CD44) on human CD34+ hematopoietic progenitor cells.
March 1999, Experimental hematology,
Copied contents to your clipboard!