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Argon green vs krypton red laser photocoagulation for extrafoveal choroidal neovascularization. One-year results in ocular histoplasmosis. The Canadian Ophthalmology Study Group. 1994

OBJECTIVE To determine whether the krypton red laser is superior to the argon green laser or vice versa for treatment of choroidal neovascularization located between 200 and 2500 microns from the center of the foveal avascular zone in patients with ocular histoplasmosis syndrome. METHODS Multicenter, randomized, controlled clinical trial. METHODS Ophthalmologic clinics throughout Canada. METHODS Patients who provided informed consent, were aged 18 years or older, and had extrafoveal membranes associated with ocular histoplasmosis syndrome. RESULTS One hundred forty-one patients were randomized, 134 (95%) of whom were determined eligible. Of the eligible patients, 128 (96%) had sufficient follow-up for the primary outcome comparison of visual acuity at 1 year. In the argon green laser group, there was a mean increase of 3 letters at 1 year, while in the krypton red laser group there was a mean decrease of 2.5 letters in visual acuity. CONCLUSIONS The krypton red laser is no better than the argon green laser for the treatment of well-defined extrafoveal choroidal neovascularization secondary to ocular histoplasmosis syndrome.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009389 Neovascularization, Pathologic A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions. Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D002829 Choroid The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA. Choriocapillaris,Haller Layer,Haller's Layer,Sattler Layer,Sattler's Layer,Choroids
D005260 Female Females
D005451 Fluorescein Angiography Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature. Fluorescence Angiography,Fundus Fluorescence Photography,Angiography, Fluorescein,Angiography, Fluorescence,Fluorescence Photography, Fundus,Photography, Fundus Fluorescence
D005584 Fovea Centralis An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)
D005654 Fundus Oculi The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed) Fundus of the Eye,Ocular Fundus,Fundus, Ocular
D006660 Histoplasmosis Infection resulting from exposure to the fungus HISTOPLASMA. African Histoplasmosis,Disseminated Histoplasmosis,Histoplasma duboisii Infection,Pulmonary Histoplasmosis,Histoplasma Infection,Histoplasma capsulatum Infection,Histoplasma Infections,Histoplasma capsulatum Infections,Histoplasma duboisii Infections,Histoplasmosis, African,Histoplasmosis, Disseminated,Histoplasmosis, Pulmonary,Infection, Histoplasma,Infection, Histoplasma capsulatum,Infection, Histoplasma duboisii
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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