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A cohort of 66 patients on maintenance haemodialysis was examined for serological (anti-HCV) and virological (HCV-RNA) evidence of infection with hepatitis C virus (HCV). Nine (13.6%) were anti-HCV positive, all of whom had detectable HCV-RNA in their serum. Statistical analysis of various risk factors (including length of time on haemodialysis, history of blood transfusion, history of renal transplantation and of previous hepatitis B infection) showed that only the length of time on haemodialysis was significantly associated with the acquisition of HCV infection. Genotypic analysis showed that five patients were infected with genotype 1 and a further two were infected with genotype 4. The latter finding is of significance because strains of genotype 4 are extremely uncommon in Western Europe. These results demonstrate that intra-unit transmission of HCV-infection took place in a group of patients on maintenance haemodialysis.
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J Waite, and
R Deaville, and
F D Thompson, and
R S Tedder
February 1991,
Australian and New Zealand journal of medicine,
G D Corcoran, and
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R S Tedder
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
G D Corcoran, and
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January 1996,
Annales de dermatologie et de venereologie,
G D Corcoran, and
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May 2002,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
G D Corcoran, and
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G D Corcoran, and
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September 2018,
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology,
G D Corcoran, and
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R S Tedder
January 1992,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
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G D Corcoran, and
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R Deaville, and
F D Thompson, and
R S Tedder
March 1998,
Journal of viral hepatitis,
