Biomaterial Database

Studies on the dense-core vesicles in the ontogenesis of locus coeruleus. I. Localization, type and density of the dense-core vesicles in locus coeruleus during rat ontogenesis. 1978

I Lolova, and J Sievers

In an attempt to clarify the function of dense-core vesicles quantitative estimation is made of their density and localization in the perikarya, axonal boutons and neuropil of rat locus coeruleus during different ontogenetic stages. The results obtained, compared with the fluorescence- and electronmicroscopic data, suggest participation of the dense-core vesicles in the neuronal development and differentiation: presence in the earliest embryonal periods, statistically significant increase in the density in the period of most intensified growth and maturing of the neuropil and axonal boutons, and change in the density of the perikarya in connection with intensified axonal transport. Quantitative data are also presented about the participation of the dense-core vesicles in synaptic transmission.

UI	MeSH Term	Description	Entries
D008125	Locus Coeruleus	Bluish-colored region in the superior angle of the FOURTH VENTRICLE floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the PERIAQUEDUCTAL GRAY.	Locus Caeruleus Complex,Locus Caeruleus,Locus Ceruleus,Locus Ceruleus Complex,Locus Coeruleus Complex,Nucleus Pigmentosus Pontis,Caeruleus Complex, Locus,Complex, Locus Caeruleus,Complex, Locus Ceruleus,Complex, Locus Coeruleus,Pontis, Nucleus Pigmentosus
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus