Biomaterial Database

Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994

N E Tsopanoglou, and E Pipili-Synetos, and M E Maragoudakis

Department of Pharmacology, Medical School, University of Patras, Greece.

The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent and selective peptidyl leukotriene receptor antagonist, SK&F 104353-Z2, abolished the angiogenic effects of leukotrienes C4 and D4 and reduced unstimulated angiogenesis. These results indicate that leukotrienes C4 and D4 promote angiogenesis in the chick chorioallantoic membrane via a receptor-mediated interaction.

UI	MeSH Term	Description	Entries
D009389	Neovascularization, Pathologic	A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.	Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D003998	Dicarboxylic Acids	Acyclic acids that contain two carboxyl groups and have the formula HO2C-R-CO2H, where R may be an aromatic or aliphatic group.	Acids, Dicarboxylic
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005321	Extraembryonic Membranes	The thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.	Fetal Membranes,Extra-Embryonic Membranes,Extra Embryonic Membranes,Extra-Embryonic Membrane,Extraembryonic Membrane,Fetal Membrane,Membrane, Extra-Embryonic,Membrane, Extraembryonic,Membrane, Fetal,Membranes, Extra-Embryonic,Membranes, Extraembryonic,Membranes, Fetal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013189	SRS-A	A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)	Slow Reacting Substance of Anaphylaxis
D017997	Leukotriene C4	The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)	LTC4,Leukotriene C,Leukotriene C-1,Leukotriene C-4,Leukotriene C1,Leukotrienes C,Leukotriene C 1,Leukotriene C 4
D017998	Leukotriene D4	One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)	LTD4,Leukotriene D,Leukotriene D-4,Leukotrienes D,Leukotriene D 4
D018077	Receptors, Leukotriene	Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.	Leukotriene Receptors,Receptors, SRS-A,SRS-A Receptors,Leukotriene Receptor,Receptors, Leukotrienes,SRS-A Receptor,Slow Reacting Substance of Anaphylaxis Receptors,Slow Reaction Substance of Anaphylaxis Receptors,Leukotrienes Receptors,Receptor, Leukotriene,Receptor, SRS-A,Receptors, SRS A,SRS A Receptor,SRS A Receptors