-transparent.png){kind=logo}
A saline extract (SE) derived from living adult Schistosoma mansoni confers high levels of resistance to challenge infection in mice and rabbits. We have carried out a number of experiments to analyse the composition of SE and to define the proteins that are rapidly released from the parasite. One of these proteins, with apparent molecular mass of 62 kDa, is recognized by polyclonal and monoclonal antibodies raised against high molecular mass cytokeratins from human epidermal cells. Immunocytochemical studies revealed a tegumental staining using the anti-cytokeratin antibody. Moreover, sera from schistosomiasis patients, as well as those from animals immunized with SE, were able to recognize this 62 kDa polypeptide as shown by immunoblot assays. These results suggest the existence of cytokeratin-containing filaments in the schistosome.
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
September 1990,
Cell and tissue research,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
April 1984,
Molecular and biochemical parasitology,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
August 1987,
Archives of biochemistry and biophysics,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
April 2002,
Molecular and biochemical parasitology,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
April 1986,
Experimental parasitology,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
January 1983,
Pharmacology & therapeutics,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
December 1963,
Annals of the New York Academy of Sciences,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
May 1969,
Parasitology,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
December 1972,
Nature,
C M Diogo, and
M C Mendonça, and
W Savino, and
N Katz, and
M Tendler
April 1983,
The Journal of parasitology,
