BIOMAT Database Logo BIOMAT Database Logo

CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma. 1994

M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Department of Urology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.

The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PCAs are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.

UI MeSH Term Description Entries
D007797 Laminin Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion. Merosin,Glycoprotein GP-2,Laminin M,Laminin M Chain,Chain, Laminin M,Glycoprotein GP 2,M Chain, Laminin
D008297 Male Males
D008819 Mice, Nude Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009368 Neoplasm Transplantation Experimental transplantation of neoplasms in laboratory animals for research purposes. Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009376 Neoplasms, Hormone-Dependent Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment. Hormone-Dependent Neoplasms,Hormone Dependent Neoplasms,Hormone-Dependent Neoplasm,Neoplasm, Hormone-Dependent,Neoplasms, Hormone Dependent
D011471 Prostatic Neoplasms Tumors or cancer of the PROSTATE. Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D011509 Proteoglycans Glycoproteins which have a very high polysaccharide content. Proteoglycan,Proteoglycan Type H
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug

Related Publications

M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Molecular cytogenetic studies of a serially transplanted primary prostatic carcinoma xenograft (CWR22) and four relapsed tumors.
September 1999, The Prostate,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
BM18: A novel androgen-dependent human prostate cancer xenograft model derived from a bone metastasis.
September 2005, The Prostate,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.
April 1997, Molecular endocrinology (Baltimore, Md.),
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft.
January 2001, Journal of andrology,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient.
November 2009, The Prostate,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Antiproliferative effect of a prostatic cell-derived activity on the human androgen-dependent prostatic carcinoma cell line LNCaP.
February 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.
November 2000, Cancer research,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft.
January 2002, The American journal of pathology,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar.
July 1996, Cancer research,
M A Wainstein, and F He, and D Robinson, and H J Kung, and S Schwartz, and J M Giaconia, and N L Edgehouse, and T P Pretlow, and D R Bodner, and E D Kursh
WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma.
December 2000, Cancer research,
Copied contents to your clipboard!