-transparent.png){kind=logo}
The effects of nerve stimulation and topical administration of substance P (SP) on the blood flow supplying the rat knee joint were measured using laser Doppler perfusion imaging. A comparison was made between the responses found in normal knees and those observed in a group of animals with unilateral chronic inflammation induced by intra-articular injection of Freund's adjuvant, 1 week prior to experimentation. In control knees, nerve stimulation produced a frequency-dependent vasoconstriction over the range of 5-30 Hz and application of SP caused a dose-dependent vasodilatation. Chronically inflamed joints showed virtually no response to either nerve stimulation or SP application, suggesting a radical alteration in sympathetic and neuropeptidergic actions.
J J McDougall, and
S M Karimian, and
W R Ferrell
January 1993,
Neuroscience,
J J McDougall, and
S M Karimian, and
W R Ferrell
July 1993,
Regulatory peptides,
J J McDougall, and
S M Karimian, and
W R Ferrell
November 1990,
Agents and actions,
J J McDougall, and
S M Karimian, and
W R Ferrell
November 1989,
Annals of the rheumatic diseases,
J J McDougall, and
S M Karimian, and
W R Ferrell
June 1992,
Regulatory peptides,
J J McDougall, and
S M Karimian, and
W R Ferrell
October 1989,
Neuroscience letters,
J J McDougall, and
S M Karimian, and
W R Ferrell
April 1981,
Naunyn-Schmiedeberg's archives of pharmacology,
J J McDougall, and
S M Karimian, and
W R Ferrell
March 1981,
Acta physiologica Scandinavica,
J J McDougall, and
S M Karimian, and
W R Ferrell
December 1996,
Brain research. Molecular brain research,
J J McDougall, and
S M Karimian, and
W R Ferrell
August 1991,
Neuroscience letters,
