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Organ blood flow, as estimated by the radioactive labelled microsphere technique, was studied in rats before and after intracaval administration of the calcium antagonist nifedipine. Intra-uterine and arterial blood pressures were registered simultaneously. Two groups of animals were investigated, one non-treated and one treated with oestradiol. After administration of nifedipine, an increase in the blood flow to the brain, the heart and the kidneys was seen in both groups of animals. However, in the uterus, blood flow was markedly increased in non-treated, but not so in oestradiol-treated animals. The arterial blood pressure and intra-uterine pressure were almost unaffected. The results suggest that nifedipine can markedly increase blood flow to the uterus of non-oestrogen-treated rats with only minor effects on intra-uterine and arterial blood pressures.
B Sandahl, and
K E Andersson, and
K F Aronsen, and
U Ulmsten
March 1980,
Hiroshima journal of medical sciences,
B Sandahl, and
K E Andersson, and
K F Aronsen, and
U Ulmsten
May 1986,
American journal of obstetrics and gynecology,
B Sandahl, and
K E Andersson, and
K F Aronsen, and
U Ulmsten
July 1988,
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B Sandahl, and
K E Andersson, and
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U Ulmsten
June 1991,
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B Sandahl, and
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U Ulmsten
December 1992,
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B Sandahl, and
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U Ulmsten
January 1990,
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B Sandahl, and
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U Ulmsten
November 1995,
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B Sandahl, and
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U Ulmsten
November 1994,
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B Sandahl, and
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U Ulmsten
June 1987,
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B Sandahl, and
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K F Aronsen, and
U Ulmsten
March 1988,
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