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Using clonogenic assay we investigated the effect of stem cell factor (SCF) on the in vitro growth of clonogenic precursor cells from acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in the presence or absence of recombinant human erythropoietin (rhEpo) or recombinant human granulocyte colony-stimulating factor (rhG-CSF). SCF as a single factor did not induce significant colony formation, and even in the presence of rhEPO or rhG-CSF it very weakly stimulated erythroid colony formation and was rarely capable of inducing myeloid colony formation by clonogenic leukemic cells. In culture dishes supplemented with SCF, both myeloid and erythroid colony formations were dramatically enhanced in MDS, regarding both colony number and size. Colony-formation abilities by MDS progenitors were improved following costimulation with SCF and rhEpo. These results suggest that SCF may have a therapeutic role in restoring hematopoiesis in patients with MDS.
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
August 1992,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
September 1992,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
January 1999,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
January 1992,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
May 1991,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
December 1995,
Blood,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
February 1991,
Experimental hematology,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
September 1994,
Stem cells (Dayton, Ohio),
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
September 2003,
Experimental hematology,
H K Wu, and
S Chiba, and
H Hirai, and
F Takaku, and
Y Yazaki
June 1993,
Molecular and cellular biology,
