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An immunohistochemical study was performed to detect the localization of nitric oxide synthase (NOS) in the rat nasal mucosa by light and electron microscopy. NOS-immunoreactive nerve fibers were observed around blood vessels and seromucous glands. They were found in the subepithelial layer and even within the epithelium. But no NOS-immunoreactivity was found in the olfactory neuroepithelium. Electron microscopy showed that NOS-immunoreactive nerve profiles were in close contact with the cytolemma of respiratory epithelial cells and acinar cells of seromucous glands. NOS-immunoreactive axon varicosities were located at a considerable distance from the smooth muscle of arterioles and small veins as well as the endothelial cells of venules and capillaries. We confirmed that NOS-containing nerves innervated the epithelium, blood vessels and seromucous glands of the nasal mucosa. These findings, collectively, suggested the possibility that nitric oxide participated in the sensory function of the epithelium, the secretory activities of the nasal gland, and the regulation of vascular tone and vascular permeability in the nasal mucosa.
T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
November 1996,
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T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
December 1990,
Brain research,
T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
November 1993,
Brain research,
T Hanazawa, and
A Konno, and
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H Esumi, and
T Chiba
October 1998,
Acta otorrinolaringologica espanola,
T Hanazawa, and
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T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
June 1998,
Brain research,
T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
March 1995,
Neuroscience,
T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
November 1995,
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T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
March 1997,
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T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
January 1993,
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T Hanazawa, and
A Konno, and
T Kaneko, and
K Tanaka, and
H Ohshima, and
H Esumi, and
T Chiba
February 1996,
American journal of respiratory and critical care medicine,
