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To investigate the markers useful for evaluating the long-term efficacy of interferon (IFN) therapy, the quantity of hepatitis C virus (HCV) RNA and two anti-HCV antibody titers (anti-N14 and anti-C-100-3 antibody) in 21 chronic hepatitis C patients were determined. In all complete responders, a sustained clearance of the virus and reductions in the anti-HCV antibody titers were observed during and after therapy. In most of the temporary responders, reductions in the HCV RNA levels and in both anti-HCV antibody titers were observed temporarily during the therapy, and relapse followed. In nonresponders, although the HCV RNA levels and anti-N14 antibody titer tended to remain unchanged or increased during and after therapy, the anti-C-100-3 antibody titers showed no tendency. These results demonstrate that the monitoring of the HCV RNA level and anti-N14 antibody titer is clinically useful for following the patient's response to IFN therapy for chronic hepatitis C.
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
April 1996,
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
October 1992,
Gastroenterology,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
August 2003,
The British journal of dermatology,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
November 1991,
Annals of internal medicine,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
July 1994,
Journal of hepatology,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
March 2000,
Gastroenterologie clinique et biologique,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
March 1993,
Antimicrobial agents and chemotherapy,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
May 1993,
Gastroenterologia Japonica,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
July 1994,
Nihon rinsho. Japanese journal of clinical medicine,
M Oketani, and
K Tanaka, and
Y Sho, and
E Maeda, and
H Miyazaki, and
T Arima
December 1998,
The American journal of gastroenterology,
