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The effects of clozapine on the dopamine and serotonin systems may underlie its atypical pharmacologic and clinical profile. To examine this hypothesis, we measured dopamine and serotonin plasma and cerebrospinal (CSF) metabolites and the relationship of these values to treatment response in 19 neuroleptic refractory and intolerant schizophrenic patients. Only a small change in the CSF and plasma homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) levels was found. However, the pretreatment CSF HVA/5HIAA ratio and, to a lesser extent, the CSF HVA level predicted treatment response. These results suggest that the modest relationship between HVA and 5-HIAA and treatment response supports the involvement of both neurotransmitters in the pathophysiology of schizophrenia.
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
March 2000,
Molecular psychiatry,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
May 1992,
The British journal of psychiatry. Supplement,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
September 1978,
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S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
January 1993,
Lancet (London, England),
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
September 1993,
The American journal of psychiatry,
S Szymanski, and
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S Pollack, and
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J Kane, and
M Kronig, and
T Cooper
February 1995,
Neuroscience letters,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
January 1989,
Psychopharmacology,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
March 1997,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
April 1999,
Neuroreport,
S Szymanski, and
J Lieberman, and
S Pollack, and
R Munne, and
A Safferman, and
J Kane, and
M Kronig, and
T Cooper
April 1984,
Pharmacology, biochemistry, and behavior,
