-transparent.png){kind=logo}
Tissue and tumor specific length variation of telomere (TTAGGG)n repeats was studied in DNAs from various normal and malignant tissues. DNA was isolated from bone marrow and blood cells, malignant tissues, and established tumor cell lines. Nonisotopic Southern hybridization revealed a reduction of telomere repeat arrays in 14 of the 35 tumors analyzed. However, other cases (60%) showed no reduction, or even an increase, in telomeric length. Our finding of elongated telomere stretches in several tumors of different origin compared with normal tissue is in contrast to previous reports describing a general shortening of terminal repeat length in colorectal cancer and neuroblastoma. We tentatively conclude that there is no general tendency to telomere reduction in malignant tissues.
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
October 2000,
Cancer letters,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
December 2007,
American journal of veterinary research,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
July 2003,
Indian journal of pathology & microbiology,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
September 2020,
Science (New York, N.Y.),
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
November 1995,
Proceedings of the National Academy of Sciences of the United States of America,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
February 2002,
Biochemical and biophysical research communications,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
April 2002,
The American journal of pathology,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
July 2003,
Cancer,
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
January 2024,
Plants (Basel, Switzerland),
H Schmitt, and
N Blin, and
H Zankl, and
H Scherthan
January 2011,
International journal of molecular epidemiology and genetics,
