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In an Illinois Cancer Center phase II trial, fludarabine phosphate was administered to a total of 14 patients (9 men, 5 women) with advanced, measurable, gastric adenocarcinoma. Fludarabine phosphate was given as a rapid intravenous (IV) bolus at a starting dose of 20 mg/m2/d for the first 5 days of a 28-day cycle. For subsequent cycles, the dose was escalated in increments of 2 mg/m2/d, provided that no toxicities greater than grade 1 were noted. In cases of grade 3 toxicity, dose reductions of 2 mg/m2/d were required, and patients who experienced grade 4 toxicities were removed from study. Receiving one complete 5-day course of fludarabine phosphate and surviving for 4 weeks on study were required for a patient to be evaluable for response. None of the patients responded to treatment. Although fludarabine phosphate was ineffective against gastric adenocarcinoma in this study, toxicity was acceptable at the 20 mg/m2/d times 5 every 28 days dose and schedule.
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
August 1992,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1994,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
July 1989,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1994,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1994,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1991,
Medical and pediatric oncology,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1995,
Investigational new drugs,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
January 1988,
Cancer chemotherapy and pharmacology,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
December 1987,
Cancer treatment reports,
L J Kilton, and
J B Ashenhurst, and
J L Wade, and
R L Schilsky, and
G Shiomoto, and
R R Blough, and
S L French, and
A B Benson
November 1994,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
