-transparent.png){kind=logo}
Evidence that nitric oxide (NO) is involved in cytokine-mediated islet beta-cell dysfunction and destruction in vitro has led to the hypothesis that increased production of NO may contribute to the pathogenesis of insulin-dependent diabetes mellitus (IDDM). This study demonstrates that oral administration of N omega-nitro-L-arginine methyl ester (an inhibitor of NO synthase) from 30 to 150 days of age significantly reduced (P < 0.05) the incidence of IDDM in diabetes-prone BB/E rats. This supports the idea that NO plays a significant role in the pathogenesis of IDDM in this animal model.
Related Publications
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
December 1995,
European journal of pharmacology,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
April 1996,
American journal of therapeutics,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
July 2004,
Biochemical pharmacology,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
January 2023,
The Journal of pharmacy and pharmacology,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
January 1999,
Journal of the Society for Gynecologic Investigation,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
April 1993,
British journal of pharmacology,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
March 1994,
European journal of pharmacology,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
January 2002,
Kidney & blood pressure research,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
December 2006,
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
R M Lindsay, and
W Smith, and
S P Rossiter, and
M A McIntyre, and
B C Williams, and
J D Baird
March 2010,
Endocrinology,
