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Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients. 1995
P Atkison, and
G Joubert, and
A Barron, and
D Grant, and
K Paradis, and
E Seidman, and
W Wall, and
H Rosenberg, and
J Howard, and
S Williams
Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.
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