BIOMAT Database Logo BIOMAT Database Logo

[Recent advances in studies of GABA receptors: neurochemical aspects]. 1995

K Kuriyama, and M Hirouchi, and S Ohkuma
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.

gamma-Aminobutyric acid (GABA) has been established as a major inhibitory neurotransmitter in the brain. The GABA-induced inhibitory transmission is mediated by two distinct types of GABA receptors which are termed as GABAA and GABAA receptors. The GABAA receptor forms a Cl- channel that consists of several subunits. The recent development of molecular cloning clarified the presence of multiple and heterogeneous molecules in the GABAA receptor subunits. Therefore, it is suggested that multiple GABAB receptors generate various functions in the brain. In contrast, the GABAB receptor exhibits various metabotropic actions for the inhibitory neurotransmission, since it is coupled with GTP-binding proteins. The GABAB receptor of approximately 80 kDa protein in its molecular weight was purified from the bovine cerebral cortex and the presence of another molecular species of the GABAB receptor was also suspected. These results indicate that studies on the molecular diversity of the GABA receptors is important for elucidating the functional roles of GABAergic neurons in the brain.

UI MeSH Term Description Entries
D007473 Ion Channels Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS. Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D011963 Receptors, GABA-A Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop. Benzodiazepine-Gaba Receptors,GABA-A Receptors,Receptors, Benzodiazepine,Receptors, Benzodiazepine-GABA,Receptors, Diazepam,Receptors, GABA-Benzodiazepine,Receptors, Muscimol,Benzodiazepine Receptor,Benzodiazepine Receptors,Benzodiazepine-GABA Receptor,Diazepam Receptor,Diazepam Receptors,GABA(A) Receptor,GABA-A Receptor,GABA-A Receptor alpha Subunit,GABA-A Receptor beta Subunit,GABA-A Receptor delta Subunit,GABA-A Receptor epsilon Subunit,GABA-A Receptor gamma Subunit,GABA-A Receptor rho Subunit,GABA-Benzodiazepine Receptor,GABA-Benzodiazepine Receptors,Muscimol Receptor,Muscimol Receptors,delta Subunit, GABA-A Receptor,epsilon Subunit, GABA-A Receptor,gamma-Aminobutyric Acid Subtype A Receptors,Benzodiazepine GABA Receptor,Benzodiazepine Gaba Receptors,GABA A Receptor,GABA A Receptor alpha Subunit,GABA A Receptor beta Subunit,GABA A Receptor delta Subunit,GABA A Receptor epsilon Subunit,GABA A Receptor gamma Subunit,GABA A Receptor rho Subunit,GABA A Receptors,GABA Benzodiazepine Receptor,GABA Benzodiazepine Receptors,Receptor, Benzodiazepine,Receptor, Benzodiazepine-GABA,Receptor, Diazepam,Receptor, GABA-A,Receptor, GABA-Benzodiazepine,Receptor, Muscimol,Receptors, Benzodiazepine GABA,Receptors, GABA A,Receptors, GABA Benzodiazepine,delta Subunit, GABA A Receptor,epsilon Subunit, GABA A Receptor,gamma Aminobutyric Acid Subtype A Receptors
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002713 Chlorine An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. Chlorine Gas,Chlorine-35,Cl2 Gas,Chlorine 35,Gas, Chlorine,Gas, Cl2
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001569 Benzodiazepines A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring. Benzodiazepine,Benzodiazepine Compounds
D001640 Bicuculline An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors. 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one

Related Publications

K Kuriyama, and M Hirouchi, and S Ohkuma
[Neurochemical and pharmacological studies on brain GABA receptors].
January 1994, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
K Kuriyama, and M Hirouchi, and S Ohkuma
Recent advances in GABA research.
May 1999, Neurochemistry international,
K Kuriyama, and M Hirouchi, and S Ohkuma
Recent Advances in In Vivo Neurochemical Monitoring.
February 2021, Micromachines,
K Kuriyama, and M Hirouchi, and S Ohkuma
Some recent advances in studies on J receptors.
January 1995, Advances in experimental medicine and biology,
K Kuriyama, and M Hirouchi, and S Ohkuma
Neurochemical and neuropharmacological aspects of histamine receptors.
January 1982, Neurochemistry international,
K Kuriyama, and M Hirouchi, and S Ohkuma
Neurochemical and neuropharmacological aspects of histamine receptors.
January 1982, Neurochemistry international,
K Kuriyama, and M Hirouchi, and S Ohkuma
Neurochemical aspects of GABA and glutamate in the hypothalamo-pituitary system.
January 1981, Advances in biochemical psychopharmacology,
K Kuriyama, and M Hirouchi, and S Ohkuma
Recent advances in DENV receptors.
January 2013, TheScientificWorldJournal,
K Kuriyama, and M Hirouchi, and S Ohkuma
Recent advances in jaundice. Surgical aspects.
January 1970, British medical journal,
K Kuriyama, and M Hirouchi, and S Ohkuma
Retracted: Recent advances in DENV receptors.
January 2013, TheScientificWorldJournal,
Copied contents to your clipboard!