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Amplification of the mdm-2 gene and overexpression of the mdm-2 protein might inactivate p53 function, and may have prognostic relevance. The present paper investigated the immunohistochemical overexpression of the mdm-2 and p53 proteins in 25 biopsy specimens of transitional cell bladder carcinomas (10 pT1 and 15 pT2 or higher stages). Five cases (20%) showed strong mdm-2 protein immunoreactivity in more than 5% of the tumor cells; 14 cases (56%) showed p53 immunoreactivity in more than 20% of the cells, and were considered as overexpressing p53 protein. Four of the five cases with strong mdm-2 immunoreactivity did not show p53 overexpression, and 13 of the 14 cases with p53 overexpression did not show mdm-2 immunoreactivity. Our data are consistent with the hypothesis that p53 overaccumulation (and hence possible p53 gene mutation) or mdm-2 overexpression (and hence possible mdm-2 gene amplification) may mirror two different and possibly complementary gene alterations, which might finally interfere with the control of cell proliferation and apoptosis. In this perspective, evaluation of the combined mdm-2/p53 protein phenotype in human bladder carcinomas could have prognostic relevance and give us better prognostic information than evaluation of the p53 protein alone.
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
June 2001,
Applied immunohistochemistry & molecular morphology : AIMM,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
January 1997,
Anticancer research,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
January 1997,
Urological research,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
August 2011,
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M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
December 1995,
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M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
September 1993,
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M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
June 1995,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
February 1995,
Clinical molecular pathology,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
November 1994,
Molecular and cellular biology,
M Barbareschi, and
S Girlando, and
G Fellin, and
U Graffer, and
L Luciani, and
P Dalla Palma
April 2000,
Cytopathology : official journal of the British Society for Clinical Cytology,
