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The depletion of CD4+ T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV-1 and associated with apoptosis. The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor. We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gp120)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+ T-cell depletion in AIDS.
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
May 2018,
Biological chemistry,
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
May 2004,
Cell death and differentiation,
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
August 2000,
Medical oncology (Northwood, London, England),
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
May 2006,
The Journal of biological chemistry,
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
October 2002,
Journal of acquired immune deficiency syndromes (1999),
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
February 2001,
Cellular immunology,
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
June 2005,
AIDS (London, England),
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
March 2003,
Journal of immunology (Baltimore, Md. : 1950),
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
August 2000,
Blood,
M O Westendorp, and
R Frank, and
C Ochsenbauer, and
K Stricker, and
J Dhein, and
H Walczak, and
K M Debatin, and
P H Krammer
November 2005,
The Journal of biological chemistry,
