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[Neuron specific enolase-producing IgD multiple myeloma with high serum amylase activity]. 1995
T Nakajima, and
T Noguchi, and
Y Kumahara, and
A Sugihara, and
T Yamazaki, and
T Iwasaki, and
T Hamano, and
E Kakishita
Japan Research Foundation for Chronic Diseases and Rehabilitation Affilated Hospital, Sakuragaoka Hospital.
A 68-year-old man who was admitted to our hospital because of general fatigue and anorexia. He was diagnosed as suffering from neuron specific enolase (NSE)-producing IgD-lambda type multiple myeloma with high activity of serum amylase, based on the detection of monoclonal IgD-lambda M-protein in the serum and urine, markedly high activities of salivary-type amylase and NSE in the serum, and immunohistochemical evidence of NSE and IgD in the myeloma cells. After two courses of alpha-IFN and VMCP chemotherapy, serum IgD, amylase and NSE decreased to normal levels. These observations indicate that NSE was ectopically produced by myeloma cells.
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