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We studied histologically the effect of systemic administration of human interferon-beta (IFN-beta) on experimental choroidal neovascularization which was caused by intensive laser photocoagulation at the posterior pole of monkey eyes. The regression of choroidal neovascularization was observed in IFN-treated monkeys. Histologically, retinal pigment epithelium (RPE) was remarkably abundant around choroidal neovascularization in the subretinal space, and the activity of neovascularization was weaker in IFN-treated monkeys than in untreated monkeys. These results indicate that IFN-beta promotes the proliferation of RPE and suppresses the activity of endothelial cells of neovascularization to cause regression of choroidal neovascularization. The results suggest that IFN-beta is clinically useful to treat the choroidal neovascularization of age-related macular degeneration.
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
October 2010,
Clinical & experimental ophthalmology,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
June 2007,
Experimental eye research,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
February 1983,
International ophthalmology,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
June 1999,
Investigative ophthalmology & visual science,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
January 1997,
Current eye research,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
January 2022,
Ophthalmic research,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
April 2011,
Nippon Ganka Gakkai zasshi,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
June 2005,
Molecular vision,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
January 2016,
Ophthalmic research,
T Tobe, and
K Takahashi, and
H Ohkuma, and
M Uyama
April 2015,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
