-transparent.png){kind=logo}
Whipple's disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple's disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple's disease who responded to therapy with trimethoprimsulfamethoxazole.
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
April 1997,
Annals of neurology,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
September 2006,
Medicina clinica,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
January 1969,
Archiv fur Psychiatrie und Nervenkrankheiten,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
January 1981,
Neuroradiology,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
January 1960,
Journal of neuropathology and experimental neurology,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
January 2012,
Internal medicine (Tokyo, Japan),
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
September 1976,
Acta neuropathologica,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
January 2010,
Handbook of clinical neurology,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
June 1979,
Revista clinica espanola,
T Q Tan, and
H Vogel, and
B R Tharp, and
C L Carrol, and
S L Kaplan
May 1963,
Neurology,
