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Human recombinant tumour necrosis factor-alpha (rhTNF-alpha) arrested the growth of Ehrlich ascites tumour (EAT) cells in vitro. It suppressed cellular glucose uptake and decreased the membrane density of glucose transporters as measured by glucose-reversible cytochalasin B binding. The glucose transporters' affinity for substrate was also reduced. However, rhTNF-alpha treatment exerted no effect on the phosphoribosyl pyrophosphate level in EAT cells. The role of rhTNF-alpha on the inhibition of glucose transport of tumour cells is discussed.
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