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Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal cortex that serves as an intermediary in sex steroid synthesis. DHEA is produced in abundance by humans and most other warm-blooded animals. Based upon previous reports demonstrating the antiviral and immunostimulatory activities of DHEA and DHEA-sulfate (DHEAS) we sought to determine whether introduction of these compounds would affect replication of feline immunodeficiency virus (FIV) in chronically infected cells. When cell number, cell viability, cellular DNA synthesis, and levels of FIV reverse-transcriptase (RT) were measured in cell cultures treated with various dilutions of DHEA or DHEAS it was found that the production of FIV RT was inhibited by DHEA at levels where cellular viability and DNA synthesis were not affected. At the concentrations tested DHEAS did not inhibit FIV replication or impact on cellular viability or proliferation.
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
February 2007,
Antiviral research,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
March 2007,
Veterinary microbiology,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
May 1993,
Journal of virology,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
May 1996,
Journal of virology,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
April 2012,
Research in veterinary science,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
September 1990,
Proceedings of the National Academy of Sciences of the United States of America,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
April 2003,
Antimicrobial agents and chemotherapy,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
October 2015,
Comparative immunology, microbiology and infectious diseases,
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
May 1995,
AIDS (London, England),
W G Bradley, and
L A Kraus, and
R A Good, and
N K Day
November 1998,
The Journal of veterinary medical science,
