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Thrombopoietin (TPO) is a growth and differentiation factor for megakaryocyte-lineage cells. The receptor for TPO, c-MPL, is a member of the hematopoietic cytokine receptor family and has previously been shown to rapidly activate one or more cytoplasmic tyrosine kinases after ligand binding. In this study, we found that activation of the TPO receptor rapidly induced tyrosine phosphorylation of two members of the Jak tyrosine kinase family, JAK2 and TYK2, but not JAK1 or JAK3, in two different factor-dependent hematopoietic cell lines. The activation of both JAK2 and TYK2 was dose- and time-dependent and was associated with rapid tyrosine phosphorylation of a series of STAT proteins including STAT1, STAT3, and STAT5. Gel-shift assays indicated that one or more of these STATs is likely to participate in the formation of specific DNA-binding complexes. The activation of tyrosine kinases and signal propagation through tyrosine phosphorylation are likely to represent important initial steps in mediating the activities of TPO in myeloid cells.
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
March 1995,
The Journal of biological chemistry,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
October 1995,
FEBS letters,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
July 1995,
Thrombosis and haemostasis,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
January 2024,
Blood,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
June 2014,
Experimental hematology,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
September 1995,
Current opinion in hematology,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
February 2010,
Blood,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
May 1999,
The Journal of biological chemistry,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
June 1999,
British journal of haematology,
M Sattler, and
M A Durstin, and
D A Frank, and
K Okuda, and
K Kaushansky, and
R Salgia, and
J D Griffin
January 2015,
Biochemical and biophysical research communications,
