-transparent.png){kind=logo}
A comparative model of the cerebrospinal fluid (CSF) system in rat, dog and man was derived from manometric data using low volume, short duration infusions into the subarchanoid space in order to describe the mechanisms governing intracranial pressure dynamics. The mathematical model indicates that steady-state elevations of intracranial pressure are regulated primarily by a nonlinear, pressure dependent outflow resistance to CSF reabsorption. While the form of the resistance relationship is similar for the three species tested, differences in the magnitude of CSF outflow parameters are apparent. Model stimulation on a digital computer suggests that parameter changes within the resistance relationship can have a profound effect on the intracranial pressure. In contrast, intracranial compliance acts only to buffer transient changes in volume prior to the establishment of steady-state CSF pressures.
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
January 1965,
Acta neurochirurgica,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
June 2012,
IEEE transactions on bio-medical engineering,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
May 1984,
Annals of neurology,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
January 1997,
European neurology,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
January 1987,
Acta neurologica Scandinavica. Supplementum,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
August 1979,
Journal of neurology, neurosurgery, and psychiatry,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
January 1989,
Zentralblatt fur Neurochirurgie,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
December 1993,
Current opinion in neurology,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
October 2015,
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery,
R N Johnson, and
C J Maffeo, and
J D Mann, and
A B Butler, and
N H Bass
September 2013,
International forum of allergy & rhinology,
