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The basal levels of plasma norepinephrine have been measured in 113 carefully characterized patients with essential hypertension, and the results have been correlated with the PRA sub-grouping and the levels of blood pressure, plasma aldosterone, plasma 18-hydroxy-deoxycorticosterone, and plasma volume. In addition, the influence of furosemide on plasma norepinephrine concentration has been assessed. Essential hypertensives, when considered as a whole, did not exhibit any significant abnormality in basal plasma norepinephrine concentration, but interesting alterations were observed in certain specific sub-groups. High renin patients had significantly elevated levels of basal plasma norepinephrine. In addition, a sub-group of the low renin population who were relatively young had reduced plasma norepinephrine conentration. In these individuals with both reduced PRA and plasma norepinephrine, the levels of both increased concomitantly to the normal range with marked salt depletion. Furosemide administration induced increases in plasma norepinephrine in all PRA sub-groups. Plasma norepinephrine correlated significantly with blood pressure in normal and low renin hypertensives, but the relationships were confined only to male subjects. Significant correlations were also observed between plasma norepinephrine and plasma aldosterine in males with normal PRA but not in the other sub-categories. No significant relationships between plasma volume and either plasma norepinephrine or blood pressure could be detected. Plasma 18-hydroxy-deoxycorticosterone was greater in males as compared with females and appeared elevated above control levels in normal and high renin essential hypertensives. Significant positive correlations between plasma aldosterone and plasma 18-hydroxy-deoxycorticosterone were observed in both males and females with normal renin hypertension. These studies have demonstrated abnormalities in basal plasma norepinephrine concentration in certain patients with essential hypertension. They also suggest that the levels of blood pressure and plasma aldosterone may be related to peripheral sympathetic activity in essential hypertension.
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
February 1977,
The American journal of medicine,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
January 1970,
Annals of internal medicine,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
January 1980,
Clinical and experimental hypertension,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
October 1979,
Journal of clinical pharmacology,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
December 1974,
Lancet (London, England),
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
December 1972,
Archives of internal medicine,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
January 1985,
European journal of clinical pharmacology,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
September 1982,
Japanese circulation journal,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
January 1974,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
A V Chobanian, and
H Gavras, and
J C Melby, and
I Gavras, and
H Jick
January 1980,
Nihon Naibunpi Gakkai zasshi,
