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A total of 19 paraffin-embedded endometrial tissue blocks were obtained from high-dose progestogen-exposed patients. A labelled streptavidin-biotin-alkaline phosphatase method was used with antibodies against von Willebrand factor (vWF) and CD34. The density of CD34 and vWF positive (CD34+ and vWF+) vessels in progestogen-exposed endometria (103 +/- 9.6/mm2 and 106 +/- 8.7/mm2) was significantly lower than in endometria from women with normal cycles (169 +/- 9.3/mm2 and 136 +/- 8.0/mm2) (P < 0.05). In women with normal menstrual cycles the concentration of CD34+ vessels was significantly higher than the number of vWF+ vessels (P = 0.0001). By comparison, the concentration of CD34+ vessels was similar to the concentration of vWF+ vessels in progestogen-exposed endometria. The ratios of vascular density as determined by vWF+ and CD34+ staining the control and progestogen groups were 0.81 and 1.05 respectively (P = 0.0001). Dilated venules were seen in the progestogen group. This study has demonstrated firstly that CD34 antibody detected the endothelial cells in a higher proportion of small endometrial vessels than vWF, and secondly that high-dose progestogen exposure significantly decreased the density of microvessels and increased the number of dilated venules in endometrium.
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
January 1987,
Gynecologic and obstetric investigation,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
October 1985,
Morphologiai es igazsagugyi orvosi szemle,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
January 2001,
Clinical hemorheology and microcirculation,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
December 2013,
The Australian & New Zealand journal of obstetrics & gynaecology,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
April 1984,
Maturitas,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
August 2005,
European journal of obstetrics, gynecology, and reproductive biology,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
October 1986,
Orvosi hetilap,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
February 1997,
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
May 2006,
Environmental research,
J Y Song, and
R Markham, and
P Russell, and
T Wong, and
L Young, and
I S Fraser
June 1992,
Arerugi = [Allergy],
