Biomaterial Database

Effect of lipid load and carbon tetrachloride on the fatty acid release from dog adipose tissue isolated in vivo. 1977

L Szlamka, and P Sándor, and E Koltay, and E Kovách

Under the influence of lipid emulsion (LipofundinR) administered into the systemic circulation of dogs, fatty acid release of adipose tissue isolated in vivo increased from 0.51 +/- 0.096 muEq/100 g/min to 3.18 +/- 0.48 muEq/100 g/min. If the lipid emulsion had been injected into the artery of adipose tissue, the fatty acid release was elevated from 0.34 +/- 0.053 muEq/100 g/min to 1.67 +/- 0.25 muEq/100 g/min. The effect could be observed in denervated adipose tissue too and in this case the fatty acid release increased from 0.40 +/- 0.053 muEq/100 g/min to 1.16 +/- 0.14 muEq/100 g/min. If CCl4 dissolved in lipid emulsion was injected into the systemic circulation, there was no significant change and a value of 0.45 +/- 0.063 muEq/100 g/min was measured. However, on administering the CCl4 dissolved in LipofundinR into the artery of adipose tissue, the fatty acid release rose from 0.34 +/- 0.053 to 1.01 +/- 0.18 muEq/100 g/min. The same manipulation on denervated adipose tissue elevated the fatty acid release from 0.40 +/- 0.053 to 0.96 +/- 0.16 muEq/100 g/min.

UI	MeSH Term	Description	Entries
D002252	Carbon Tetrachloride Poisoning	Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	CCl4 Poisoning,Poisoning, CCl4,Poisoning, Carbon Tetrachloride,CCl4 Poisonings,Carbon Tetrachloride Poisonings,Poisonings, Carbon Tetrachloride
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005217	Fat Emulsions, Intravenous	Emulsions of fats or lipids used primarily in parenteral feeding.	Intravenous Fat Emulsion,Intravenous Lipid Emulsion,Lipid Emulsions, Intravenous,Emulsion, Intravenous Fat,Emulsion, Intravenous Lipid,Emulsions, Intravenous Fat,Emulsions, Intravenous Lipid,Fat Emulsion, Intravenous,Intravenous Fat Emulsions,Intravenous Lipid Emulsions,Lipid Emulsion, Intravenous
D005230	Fatty Acids, Nonesterified	FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.	Fatty Acids, Free,Free Fatty Acid,Free Fatty Acids,NEFA,Acid, Free Fatty,Acids, Free Fatty,Acids, Nonesterified Fatty,Fatty Acid, Free,Nonesterified Fatty Acids
D005260	Female		Females
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014655	Vascular Resistance	The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.	Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic