Role of mast cells and basophils in asthma. 1995

A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
University Medicine, Southampton General Hospital, UK.

UI MeSH Term Description Entries
D008407 Mast Cells Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR. Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D010450 Endopeptidases A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS. Endopeptidase,Peptide Peptidohydrolases
D010972 Platelet Activating Factor A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION. AGEPC,Acetyl Glyceryl Ether Phosphorylcholine,PAF-Acether,Phosphorylcholine, Acetyl Glyceryl Ether,1-Alkyl-2-acetyl-sn-glycerophosphocholine,Platelet Aggregating Factor,Platelet Aggregation Enhancing Factor,Platelet-Activating Substance,Thrombocyte Aggregating Activity,1 Alkyl 2 acetyl sn glycerophosphocholine,Aggregating Factor, Platelet,Factor, Platelet Activating,PAF Acether,Platelet Activating Substance
D011509 Proteoglycans Glycoproteins which have a very high polysaccharide content. Proteoglycan,Proteoglycan Type H
D006636 Histamine Release The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects. Histamine Liberation,Histamine Liberations,Histamine Releases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D001491 Basophils Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes. Basophil
D012697 Serine Endopeptidases Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis. Serine Endopeptidase,Endopeptidase, Serine,Endopeptidases, Serine
D015289 Leukotrienes A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system. Leukotriene

Related Publications

A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 1989, Annales de biologie clinique,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 2005, Advances in immunology,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
December 1993, Nihon Kyobu Shikkan Gakkai zasshi,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 1998, Canadian respiratory journal,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 1995, Chemical immunology,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
March 2018, Immunological reviews,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
June 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 1995, Chemical immunology,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 1996, Allergy and asthma proceedings,
A E Redington, and R Polosa, and A F Walls, and P H Howarth, and S T Holgate
January 2007, Clinical allergy and immunology,
Copied contents to your clipboard!