The Authors report their experience of laparoscopic cholecystectomy (VLC) from October 1993 to May 1994. Fourty patients underwent laparoscopic cholecystectomy for gallstone disease; two patients required laparotomic conversion for Mirizzi's syndrome, while complications were observed in two cases. Only one case required laparotomy in third post-operative day for duodenal electrocautery injury. Diagnostic procedures and surgical technique are also reported. On the basis of their experience, the Authors conclude that mini-invasive surgery doesn't mean less difficult surgery, but a good knowledge of the anatomy and a thorough experience of biliary open and reparative surgery are necessary before laparoscopic cholecystectomy is performed.