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Production of term offspring by in vitro fertilization using old mouse spermatozoa. 1995
T Wakayama, and
K Tanemura, and
J Suto, and
K Imamura, and
K Fukuta, and
H Mori, and
K Kuramoto, and
M Kurohmaru, and
Y Hayashi
Department of Veterinary Anatomy, Faculty of Agriculture, University of Tokyo, Japan.
We successfully produced offspring of old male BDF1 mice using in vitro fertilization. Although 7 old male mice (33 months of age) were infertile and revealed frequent degeneration in the seminiferous epithelia, 4 of them had spermatozoa in the caudae epididymides. The IVF rate of their sperm with eggs from young ICR mice was very high (82.0%). The production rate of offspring was also satisfactory (61.6%). The present study indicates that the IVF method is useful for producing offspring of aged male mice.
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