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Furosemide (F) was administered to rabbits intravenously and intraduodenaly and the biliary excretion was studied. The major metabolite excreted in bile was furosemide glucuronide (FG). F and acyl migration isomers of FG (FG-iso) were also excreted in bile. The biliary excretion rates of total F (F+FG+FG-iso) following intraduodenal administration of F were much smaller than those following intravenous administration. The fraction of (F+FG-iso) in bile following intraduodenal administration of F were larger than those following intravenous administration. Stability of FG or FG-iso in bile and supernatant solution of the duodenum homogenate of rabbits was studied. FG was unstable in both media and its degradation followed apparent first-order kinetics in both media. In bile, FG degraded to produce several FG-iso and F, while in the supernatant solution of the duodenum homogenate, it hydrolyzed immediately to F. FG-iso were hardly detected in the supernatant solution. These results indicated that FG excreted in bile degraded easily to FG-iso and F. FG might easily hydrolyze to F enzymatically in the duodenum, and the resultant F might be reabsorbed from the intestinal tract. Unabsorbed FG-iso and F might be excreted in the feces.
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N Yagi, and
K Oda, and
H Kenmotsu, and
M Takada, and
H F Chen, and
E T Lin, and
L Z Benet
January 1990,
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January 1983,
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H Sekikawa, and
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December 1968,
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June 2001,
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L Z Benet
January 1977,
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H Sekikawa, and
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L Z Benet
April 1953,
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H Sekikawa, and
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L Z Benet
October 1980,
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H Sekikawa, and
N Yagi, and
K Oda, and
H Kenmotsu, and
M Takada, and
H F Chen, and
E T Lin, and
L Z Benet
August 1971,
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H Sekikawa, and
N Yagi, and
K Oda, and
H Kenmotsu, and
M Takada, and
H F Chen, and
E T Lin, and
L Z Benet
March 1996,
Hepatology (Baltimore, Md.),
H Sekikawa, and
N Yagi, and
K Oda, and
H Kenmotsu, and
M Takada, and
H F Chen, and
E T Lin, and
L Z Benet
December 1974,
The Journal of pharmacy and pharmacology,
