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Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. 1995
G T De Sanctis, and
M Merchant, and
D R Beier, and
R D Dredge, and
J K Grobholz, and
T R Martin, and
E S Lander, and
J M Drazen
Combined Program in Pulmonary and Critical Care Medicine, Brigham Women's Hospital, Boston, Massachusetts 02115, USA.
Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome-wide survey of airway hyperresponsiveness in any mammal.
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