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Plasma concentration, hepatic uptake and biliary excretion of intravenously administered rose bengal was determined in rats pretreated with phenobarbital (50 mg/kg) daily, for four days). After an initial (0--16 min) rapid fall in plasma rose bengal concentration caused by hepatic uptake of the dye, the curves in control and pretreated rats did not differ from each other either after administration of a small (5 mg/kg) or a large (50 mg/kg) dose. Hepatic rose bengal concentration was significantly lower in pretreated animals than in the control group. Since liver weight was higher in the phenobarbital pretreated animals than in the controls, the total amount of rose bengal taken up by the liver did not differ in the two groups. The biliary excretion of low dose (5 mg/kg) rose bengal was significantly higher in phenobarbital pretreated than in the control rats but with doses of 50 mg/kg and 100 mg/kg no difference was observed. These doses of rose bengal diminished the increased bile flow caused by phenobarbital.
A Gógl, and
C S Ruzsa, and
E Fischer
September 1973,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
A Gógl, and
C S Ruzsa, and
E Fischer
May 1987,
The Journal of pharmacy and pharmacology,
A Gógl, and
C S Ruzsa, and
E Fischer
January 1979,
Acta physiologica Academiae Scientiarum Hungaricae,
A Gógl, and
C S Ruzsa, and
E Fischer
June 1985,
Archives internationales de pharmacodynamie et de therapie,
A Gógl, and
C S Ruzsa, and
E Fischer
January 1980,
Acta biologica et medica Germanica,
A Gógl, and
C S Ruzsa, and
E Fischer
February 1975,
Biochemical pharmacology,
A Gógl, and
C S Ruzsa, and
E Fischer
October 1976,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
A Gógl, and
C S Ruzsa, and
E Fischer
February 1972,
Pediatric research,
A Gógl, and
C S Ruzsa, and
E Fischer
May 1968,
Revue francaise d'etudes cliniques et biologiques,
