BIOMAT Database Logo BIOMAT Database Logo

Significance of chromosome 1p loss of heterozygosity in neuroblastoma. 1995

J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadepphia School of Medicine 19104, USA.

We analyzed 156 primary neuroblastoma tumor samples for loss of heterozygosity at the distal short arm of chromosome 1 (1p LOH). We also compared 1p LOH with known clinical and genetic prognostic variables as well as patient outcome. 1p LOH was detected in 30 of 156 tumors (19%) and was strongly associated with adverse clinical and biological features. 1p LOH was also strongly predictive of a poor outcome in univariate analyses (estimated 4-year survival, 32 +/- 10% SE versus 76 +/- 5% SE; P < 0.001). However, the prognostic value of 1p LOH was equivocal when stratified for amplification of the MYCN oncogene (P = 0.16). We conclude that 1p LOH is an important component of a pattern of genetic abnormalities in neuroblastoma associated with an aggressive clinical course.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D009447 Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) Neuroblastomas
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002878 Chromosomes, Human, Pair 1 A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification. Chromosome 1
D005260 Female Females
D005784 Gene Amplification A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. Amplification, Gene
D005819 Genetic Markers A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event. Chromosome Markers,DNA Markers,Markers, DNA,Markers, Genetic,Genetic Marker,Marker, Genetic,Chromosome Marker,DNA Marker,Marker, Chromosome,Marker, DNA,Markers, Chromosome
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Loss of heterozygosity for chromosome 1p in familial neuroblastoma.
October 1997, European journal of cancer (Oxford, England : 1990),
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Allelic loss of chromosome 1p in neuroblastoma.
June 1996, The New England journal of medicine,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Clinical significance of chromosome 1p/19q loss of heterozygosity and Sox17 expression in oligodendrogliomas.
January 2014, International journal of clinical and experimental pathology,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Loss of heterozygosity at chromosome 1p in human breast cancer.
October 1996, International journal of oncology,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p.
February 2000, The Journal of molecular diagnostics : JMD,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Loss of heterozygosity on chromosome 14 in neuroblastoma.
January 1991, Progress in clinical and biological research,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Frequent loss of heterozygosity on chromosome 14q in neuroblastoma.
March 1989, Cancer research,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.
May 1991, Oncogene,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
[Loss of heterozygosity of chromosome 1p/19q and p53 protein expression in oligodendroglioma].
July 2009, Zhonghua bing li xue za zhi = Chinese journal of pathology,
J M Maris, and P S White, and C P Beltinger, and E P Sulman, and R P Castleberry, and J J Shuster, and A T Look, and G M Brodeur
[A preliminary study of loss of heterozygosity on chromosome 1p in primary hepatocellular carcinoma].
February 1999, Zhonghua bing li xue za zhi = Chinese journal of pathology,
Copied contents to your clipboard!