BIOMAT Database Logo BIOMAT Database Logo

Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid. 1995

H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Department of Nuclear Medicine, Kyoto University, Faculty of Medicine, Japan.

It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (99mTc (V) DMSA) can be changed into 99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of 99mTc. The method of labelling of 99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated 99mTc (III) DMSA into 99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.

UI MeSH Term Description Entries
D007553 Isotope Labeling Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms. Isotope Labeling, Stable,Isotope-Coded Affinity Tagging,Isotopically-Coded Affinity Tagging,Affinity Tagging, Isotope-Coded,Affinity Tagging, Isotopically-Coded,Isotope Coded Affinity Tagging,Labeling, Isotope,Labeling, Stable Isotope,Stable Isotope Labeling,Tagging, Isotope-Coded Affinity,Tagging, Isotopically-Coded Affinity
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D011933 Reagent Kits, Diagnostic Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use. Diagnostic Reagent Kits,Diagnostic Reagents and Test Kits,Diagnostic Test Kits,In Vitro Diagnostic Device,In Vitro Diagnostic Devices,In Vitro Diagnostic Medical Device,In Vitro Diagnostic Medical Devices,Kits, Diagnostic Reagent,Diagnostic Reagent Kit,Diagnostic Test Kit,Kit, Diagnostic Reagent,Kit, Diagnostic Test,Kits, Diagnostic Test,Reagent Kit, Diagnostic,Test Kit, Diagnostic,Test Kits, Diagnostic
D004113 Succimer A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. DMSA,Dimercaptosuccinic Acid,2,3-Dimercaptosuccinic Acid,Butanedioic Acid, 2,3-Dimercapto-, (R*,S*)-Isomer,Chemet,Ro-1-7977,Succicaptal,Succimer Antimony Sodium Salt, (R*,S*)-Isomer,Succimer, (R*,R*)-(+,-)-Isomer,Succimer, Dipotassium Salt,Succimer, Disodium Salt,Succimer, Monosodium Salt,Succimer, Rhenium Salt,Succimer, Tin Salt,Tin Dimercaptosuccinate,meso-Dimercaptosuccinic Acid,2,3 Dimercaptosuccinic Acid,Acid, 2,3-Dimercaptosuccinic,Acid, Dimercaptosuccinic,Acid, meso-Dimercaptosuccinic,Dimercaptosuccinate, Tin,Dipotassium Salt Succimer,Disodium Salt Succimer,Monosodium Salt Succimer,Rhenium Salt Succimer,Ro 1 7977,Ro17977,Tin Salt Succimer,meso Dimercaptosuccinic Acid
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions

Related Publications

H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
The chemical identity of pentavalent technetium-99m-dimercaptosuccinic acid.
May 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Pentavalent technetium-99m-dimercaptosuccinic acid scintigraphy in renal osteodystrophy.
March 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Uptake of pentavalent technetium-99m dimercaptosuccinic acid in idiopathic synovial chondromatosis.
August 1995, Annals of nuclear medicine,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Technetium-99m pentavalent dimercaptosuccinic acid imaging in patients with pituitary adenomas.
July 1995, European journal of endocrinology,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Technetium-99m-pentavalent dimercaptosuccinic acid uptake in Hurthle cell tumor of the thyroid.
June 1993, Journal of nuclear biology and medicine (Turin, Italy : 1991),
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
In vitro and in vivo studies with pentavalent technetium-99m dimercaptosuccinic acid.
December 1996, European journal of nuclear medicine,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Pentavalent technetium-99m dimercaptosuccinic acid uptake in primary amyloidosis: comparison with autopsy findings.
January 1997, Radiation medicine,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Pentavalent technetium-99m dimercaptosuccinic acid scintigraphy is useful in diagnosis and localization of neuroblastoma.
September 1992, Postgraduate medical journal,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Simple and reliable preparation of pentavalent 99Tcm-dimercaptosuccinic acid at alkaline pH without oxygen bubbling.
June 2001, Nuclear medicine communications,
H Kobayashi, and K H Suzuki, and H Sakahara, and Z S Yao, and A Yokoyama, and J Konishi
Can technetium-99m-mercaptoacetyltriglycine replace technetium-99m-dimercaptosuccinic acid in the exclusion of a focal renal defect?
December 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Copied contents to your clipboard!