-transparent.png){kind=logo}
The volatile anesthetic, Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether), was investigated at anesthetic concentrations to determine its effects on reproduction in rats treated prior to mating, on fetal development in rats and rabbits when administered during various stages of gestation, and on fetal survival in rats treated during late pregnancy. No adverse reproductive effects were observed, and no evidence of teratogenic activity was obtained. Fetal survival was low in rats exposed during late pregnancy but whether or not this finding is related to Isoflurane exposure requires confirmation.
Related Publications
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
July 1976,
Journal of toxicology and environmental health,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
January 1982,
Arzneimittel-Forschung,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
January 1983,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
November 1976,
Toxicology and applied pharmacology,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
August 1969,
Arzneimittel-Forschung,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
January 1993,
Reproductive toxicology (Elmsford, N.Y.),
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
April 1974,
Toxicology and applied pharmacology,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
July 1970,
Pharmaceutica acta Helvetiae,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
June 1975,
Toxicology and applied pharmacology,
G L Kennedy, and
S H Smith, and
M L Keplinger, and
J C Calandra
December 1965,
Arzneimittel-Forschung,
