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Soman reduced blood and brain cholinesterase (ChE) activity to less than 15% and increased cerebral acetylcholine (ACh) levels to 137.4% of control. When pyridostigmine (P) was used as a prophylactic adjunct, it reduced blood ChE activity to 31.6% of control, failed to significantly alter brain ChE activity, and protected more than 70% of the blood (but not brain enzyme) from phosphonylation by soman. Benactyzine (B) was more effective than atropine (A) in reducing cerebral ACh concentrations, while a combination of the two was more effective than either alone. A prophylaxis of P + A + B was effective in controlling ACh levels in rats poisoned with one LD50 dose of Soman. Since P did not diminish the effects of the cholinolytics on cerebral ACh, this (together with the enzyme data) suggests that the two cholinolytics alone provided the central protection.
D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
January 1999,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
January 1984,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
November 2000,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
January 1970,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
July 1986,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
May 1983,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
January 1981,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
January 1982,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
May 1982,
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D L Stitcher, and
L W Harris, and
W C Heyl, and
S C Alter
September 1984,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
