Biomaterial Database

Self-activation of N-phosphoamino acids and N-phosphodipeptides in oligopeptide formation. 1995

Y Zhao, and Y Ju, and Y Li, and Q Wang, and Y Yin, and B Tan

Department of Chemistry, Tsinghua University, Beijing, Peoples Republic of China.

N-Phosphorylamino acids and N-phosphoryldipeptides can self-activate to give the oligopeptide. An intramolecular mixed anhydride intermediate might exist during the self-activating process. A peptide bond was formed from the N-terminus to the C-terminus by the '1 + n' mechanism, which was similar to the rRNA-peptide biosynthesis pathway.

UI	MeSH Term	Description	Entries
D008969	Molecular Sequence Data	Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.	Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009842	Oligopeptides	Peptides composed of between two and twelve amino acids.	Oligopeptide
D010766	Phosphorylation	The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.	Phosphorylations
D002384	Catalysis	The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.	Catalyses
D004151	Dipeptides	Peptides composed of two amino acid units.	Dipeptide
D000595	Amino Acid Sequence	The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.	Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D049148	Aminoacylation	A reaction that introduces an aminoacyl group to a molecule. TRANSFER RNA AMINOACYLATION is the first step in GENETIC TRANSLATION.	Activation of Amino Acids,Amino Acylation,Acids Activation, Amino,Acids Activations, Amino,Acylation, Amino,Acylations, Amino,Amino Acids Activation,Amino Acids Activations,Amino Acylations,Aminoacylations