Cynical hostility has been linked to coronary heart disease (CHD), and there is mixed support for the hypothesis that cynical hostility may contribute to CHD through exaggerated cardiovascular responses to anger-provoking stressors. The present study tested the influences of cynical hostility on affective and cardiovascular responses to provocation in 68 undergraduate men. Subjects were divided into high and low cynical hostility groups by a median split on Cook-Medley Hostility Scale scores, and half of the subjects in each group were harassed during competition on a video game. High hostile subjects reported greater anger than low hostile subjects during the competition, independently of harassment, and harassment produced stronger feelings of mistreatment, independently of hostility. Harassed subjects experienced larger systolic blood pressure responses only during an affect rating period after the competition, but the responses were not influenced by hostility. These findings provide further evidence that cynical hostility, anger, and cardiovascular reactivity are not simply nor consistently related.